The Science

Active Gases: Fighting Bacteria at a Molecular Level

Foot odour and sweat are biological problems. Sikoped's active gas technology tackles them with a precise, science-backed approach — not fragrance, not powder, not guesswork.

Understanding the Enemy: Odour-Causing Bacteria

The human foot has over 250,000 sweat glands — more per square centimetre than almost anywhere else on the body. Inside a closed shoe, this creates a warm, moist, oxygen-limited environment that is ideal for bacterial growth.

The primary culprits are anaerobic bacteria such as Brevibacterium linens and Staphylococcus epidermidis. These microorganisms metabolise the proteins and fatty acids in sweat, producing volatile organic compounds (VOCs) — specifically isovaleric acid and methanethiol — which are responsible for the characteristic smell of foot odour.

Because these bacteria thrive in low-oxygen conditions, simply washing your feet or changing socks only provides temporary relief. The moment the shoe environment becomes warm and moist again, bacterial populations rapidly rebuild.

How Active Gases Disrupt Bacterial Biology

Sikoped insoles release a controlled concentration of active gases that interfere with bacterial life processes at a cellular level.

01

Cell Membrane Disruption

The active gases permeate the outer membrane of bacterial cells, compromising their structural integrity. Without an intact membrane, bacteria cannot regulate their internal environment and begin to break down.

02

Metabolic Interference

The gases inhibit key enzymatic processes that bacteria rely on to metabolise sweat compounds. By blocking these metabolic pathways, the production of the volatile acids that cause odour is halted at the source.

03

Oxidative Action on VOCs

Active gases also react directly with the volatile organic compounds already present in the shoe environment, oxidising them into odourless, harmless by-products — providing immediate relief while the deeper bacterial action takes hold.

04

Inhibiting Biofilm Formation

Bacteria in shoes often form biofilms — protective colonies that are highly resistant to conventional treatments. The active gases penetrate and disrupt these biofilm structures, preventing bacteria from re-establishing resistant colonies.

The Link Between Bacteria and Excessive Sweating

Sweating itself is a normal physiological response. However, when bacteria are present in high concentrations, they produce compounds that can stimulate further sweat gland activity — creating a feedback loop where more bacteria leads to more sweat, which in turn feeds more bacteria.

By reducing the bacterial load inside the shoe, Sikoped's active gases help break this cycle. As bacterial populations decline, the biochemical signals that amplify sweat production are reduced, leading to a measurable decrease in foot moisture over time.

Continuous, Sustained Release

Unlike a one-time treatment, the compound within Sikoped insoles is formulated for sustained release. Throughout the day — and across multiple wears — the insole continues to emit active gases at a concentration effective against bacteria but safe for the wearer. This sustained action is what produces long-term results rather than temporary relief.

250,000+Sweat glands per foot
DaysTo notice a significant improvement
Long-termResults with continued use

Safe for Everyday Use

The active gases operate within the enclosed environment of the shoe — they do not come into direct prolonged contact with skin at harmful concentrations. The formulation is designed to be effective against bacteria while remaining safe for daily wear.

Put the Science to Work

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